Capsulated Systems, Inc is proud of our reputation in the microencapsulation industry, and we stand by our more than three decades of experience in the field. Our headquarters, industrial encapsulation labs, pilot plant (that can make batches of ten pounds each), and manufacturing plant (computerized production) (see above) are located in Miamisburg, OH. The plant has an annual capacity of one million pounds of dry capsules and five million pounds of capsules in slurry form. This capacity can easily be quadrupled in the same facility with minimal additional equipment. In addition, CSI maintains a production facility in Springfield, OH that has an annual capacity of 125,000 pounds of dry capsules.

In addition, CSI's pharmaceutical research lab is located in Ithaca, NY in the Cornell Business and Technology Park. The purpose of this effort, which is totally unrelated to the industrial side in Ohio, is to use our understanding of controlled release techniques and apply them to the pharmaceutical industry. Then the plan is to locate partners who have extensive experience in the pharmaceutical industry to develop and market the products under a license from CSI.



PROPRIETARY PRODUCTS
AVCAP and MACAP Macroencapsulation Coating
While working on some projects requiring particularly strong, impermeable capsule walls, scientists at CSI theorized that a version of the wall material might be applied as a macroencapsulation conformal coating. This idea has fostered an extraordinarily successful program, a patent and certification of a resultant conformal coating for electronic circuits(AVCAP) for the Department of Defense Qualified Products List for MIL-I-46058C which permits its use for protection of sensitive and valuable defense electronics equipment.



The macroencapsulation conformal coatings systems developed at CSI meet the challenges of moisture and humidity protection of electronic hardware. CSI's macroencapsulation process uses an organic polymer which wraps itself around the surface to be encapsulated to provide uniform protection from contamination. It is easily applied by dip, brush or spray techniques. Some of it's advantages are:


  • Superior Moisture/Oxygen Resistance
  • Pin-Hole Free Coating
  • Flexibility
  • Repairability
  • Excellent Adhesion
  • Protection of Electromigration
  • Excellent Heat Dissipation
  • Thermal Shock Resistance
  • Transparency (UV Tint Available)
  • Thin Film, 1 -2 mils
  • No Shrinkage
  • No Cracking (no plasticizers)
  • Chemical Resistance
  • Easy, Low-Cost Application
  • Compatibility with Other Coatings for Repair/Rework Purposes(Urethanes and Epoxies)

    Additionally, MACAP, a similar product to AVCAP, is being tested as a protective coating for metal structural components (concrete reinforcement bars, bridge and building beams, etc.) Results, thus far, are excellent. MACAP's superior adhesion qualities, pin-hole free coating, moisture/humidity resistance and thermal shock resistance properties exhibit promise that it may be the corrosion inhibition system of the future.

    Finally, this polymeric material provides CSI with a unique capability to microencapsulate aqueous based materials heretofore unheard of. Such materials as water/glycerine, sulfuric acid(2% concentration), sodium hydroxide(5% concentration), and pesticides can now be encapsulated and isolated into a free flowing powder using this patented system.


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    OTHER INDUCTRIAL PRODUCTS

  • ZNCAP - A zinc-rich primer employing microencapsulation technology to produce a superior, corrosion inhibiting coating.
  • EELS - A patented system for encapsulating the phosphors used in electroluminescent lighting to prevent degradation due to humidity. Greatly increases the life of the lamp.
  • CAPLOK - A threaded fastener adhesive coating system.
  • SILCAP - An aqueous-based, dry protective coating.
  • FY'R'CAP - A microencapsulated fire retardant material.
  • SPOT-A-WAY - CSI's only consumer product incorporating microencapsulated 1,1,1 Trichloroethane in a personal cleaning configuration for organic stains.
  • LUBRICAP - A microencapsulated lubrication system for incorporation into thermoplastic and elastomeric compounds to provide lubrication upon exposure to friction.
  • PHASE-CAP - An encapsulated phase change material (usually octadecane or eicosane) used to absorb heat.
  • AGRICAP - A system for encapsulating herbicides and providing nearly zero order (straight line) release over a 60 - 90 day period regardless of the presence of moisture.
  • STETHEATER - A system that heats medical devices to body temperature to provide comfort to patients during medical exams using an exothermic chemical reaction.
  • KWIK CONNECT - A microencapsulated PVC Cement sold by Carlon on pre-coated PVC couplings. Has received UL certification and CSI holds five patents.

     

    PHARMACEUTICALS

    Prolonged Release Local Anesthetic 

    Pain management after surgery often starts with an injection of a local anesthetic as part of surgery.  This, however, provides pain relief for only a matter of hours after surgery for a single injection, even for local anesthetics which are deemed relatively longer lasting.  In many cases, an augmentation agent is believed needed to extend the action of the local anesthetic.  The patient can then be prescribed medications such as hydrocodone, percoset, vicadin, or other opiates or opiate-like materials.  Opiates operate on the central nervous system to manage pain for the next 5-7 days, after which the pain subsides to a level that can be controlled by over-the-counter pain killers such as ibuprophen, acetaminophen, or aspirin.  However, opiates present potential problems with addiction, abuse, adverse reaction, and limiting of patient activity. 

    A need exists to find better, more efficient pain management approaches, including longer lasting pain relief from local anesthetics which can eliminate or reduce the need for opiate usage and reduce or eliminate side effects.  This is particularly true when there are limits on the volume of anesthetic which can be injected.  Furthermore, a need exists for prolonged local anesthetics that do not require augmentation agents.  Some augmentation agents are condition-specific for particular deceases, such as cancer, or others, such as steroids, are prone to produce side effects.

                CSI’s system relied on our knowledge of microencapsulation and time release techniques to develop a composition made of a number of microparticles in which microparticles are made of different chemical backbones to release at different rates over different times. The system is efficient in that it typically has at least 50% loading going up to 80% loading compared to similar systems that max out at 30% loading, This allows for more drug to be released in the least particle volume.

    ADVANTAGES OF CSI PHARMACEUTICAL MICROPARTICLE SYSTEM

    1.      extended relief from pain.

    2.      ability to reduce or eliminate the need for augmentation agents, epinephrine and

    other vasoconstrictors.

    3.      lidocaine-based.

    4.      injectable through an 18 gauge needle.

    5.      provides continuous pain relief for at least 6 days post-surgery.

    6.      allows for full sensory response recovery.

    7.      causes no nerve nor tissue damage.

    8.      causes minimal motor response suppression.

    9.      polymer is quickly and fully absorbable in a few days time period, and not in  

    terms of months.

    10.  doe not cause side effects.

    11.  minimizes the need for opiates and opiate-like medications.

    12.  supersedes side effects of opiates.

    13.  supersedes the potential for misuse and abuse of opiates.

    14.  allows for speedy recovery and physical therapy post-surgery.

    15.  all the components of the microparticles are FDA approved.

     

    CAPSULATED SYSTEMS, INC.

    LABORATORY PRODUCTS LIST OF ENCAPSULATED CHEMICALS

    AS OF APRIL  01, 2010


    The following chemicals have been microencapsulated in CSI's laboratories in research quantities ranging from 100 grams to 5 pounds:
     

        A

    1.   Acetonitrile,  Adhesive - Carters Rubber Cement *,  Air,  Algenic acid,5.  Aluminum Flake,  4-aminophenyl sulfone,  Ammonium Metavanadate,  Ammonium Persulfate,  Ancamide 220,   Ancamine TL,  Antimony oxide,   Ascorbic Acid *,    Atrazine,    AVCAP,

    B

    15.   Benzoyl Peroxide,   Boron trifluoride,   Butyl Acetate,   Butyl Buterate,               1,3 Butylene glycol dimethacrylate,    Butylmethacrylate, t-Butyl Perbenzoate (TBPB)

    C

    22.    Calcium Bromide,  Calcium Carbonate, Calcium Chloride (Wellbrom),         Caplok,  Carbon iron powder,  Carbon Tetrachloride *, Carbonyl Iron Powder, Castor oil, Cellulose Acetate Buterate (CAB),      Cellulose Acetate Phthalate (CAP),  Chlordane,  Chloroform *,           Christo-Lube MCG-405,   Citric Acid *,  Citronella Lamp Oil,  Clearcap,       Coal Dust,  Coleman Fuel,  Copper Sulfate,   Cottonseed oil,  Crystal Violet Lactate(CVL),  Cumene hydroperoxide,  Cyclohexane *,  Cyclohexanone

    D 

    47.  Desmadur DA Catalyst,  Dibutyltin Dilaurate,  Dichloroethane,               Diethylene triamine (DETA), Diethylene triamine LiCl (DETA LiCl), Dimethyl amino hydrochloride, Dimethyl sulfoxide (DMSO),              Dioxane,  d-Limonenedimercaptan (dLDM),  DMPT 2690,  Drake oil

    E

    58.  Electrolumenescent Phosphors (EELs)*,Eicosane,  Epon 8132, Epon 828 & 830, Epon 9215, Epon T-1, Epoxy Resin Araldite PY-307-1,          Epoxy Resin LS-625, Ethanol amine, Ethyl amyl ketone (EAK),  Ethyl Cellulose,   Ethyl Ether,  EVA Hydrolysis *,

    F

    71.   Fire Retardent *,  Fish Food *,  Flame Retardants (Fyrol FR-2 - Fyrcap & Formula XII)*,  Fluorescent dyes,        Fluorinert FC-43 (3M),   Fragrance Volcano & Iceberg,  Freon TF & MF *,   Fumed Silica, 

    G

    81.     Gasoline,  Gelatin 2-Way,   Gluteraldehyde, Glycerine *,Graphite & Magnetite,   Grease(Christo-Lube MCG-405 & Tribolube 26),             Grease/Heptane,   Gulf Lite,

    H                    

    91.    Heptane,  Herbicide – Lilly *,  HEVA film *,   Hexadecane,            Hexamethylene tetramine, Hexane *,1,6 Hexanediol dimethacrylate (HDDM), HiVax fish vaccine,  Hydrazine HOAC, Hydrazine(rocket fuel),        Hydrochloric Acid (2% concentration), Hydrogen Peroxide

    I   

    104.     Imidazole,  Inks *,  Iron Nitrate,  Iron Oxide,  Iron Stearate,  Isoheptane,         Isophorone

    L

    111.   Lacolene, Latex Adhesive 2072,  L-carvone,   Lead oxide, Leuco dyes,   Levasint E,   Lidocaine solid and 2% solution, Lotions,   Lupersol PDO

    M

    120.     MACAP,  Magnaquench Blended Powder,  Magnesium chloride,              Magnesium Hydroxide,  Magnetite,  Magnetite ferrous oxide,        Manganese Dioxide MnO2 *, Manganese oxide,    Menthol 100% & 50/50 Menthol/Mineral Oil, Mercaptan (T-Dodecyl & N-tetradecy (NTM)) Metalochlor Technical Dual VARCSI, Methyl Cellulose EGMME,         Methyl Isobutyl Ketone (MIBK),   Methyl Palmitate, Methyl salicylate, .          3-Methyltetrahydropyran,  Methyl Violet, Methylcyclohexane,  Methylene Blue & Milori Blue*,   Microthene,  Mineral Spirits *,Mondur   CB-75,           Monocrotophos

    N

    143.   Nickle Stearate,  Nicotine *,   Nicotine Carbonate,  Nicotine Citrate *,          Nicotine Phosphate *

    O

    148.   Octadecane, Octafluorotoluene,  2-Octanone (Methyl Hexyl Ketone),         Octyl decyl alcohol or ether,  Oleic Acid - Emersol 210,   Orthene *

    P

    154.  Paraffin wax & graphite(toner) oil, Paraquat,  PCM - Phase Change Materials,  Perfluoro 1,3 Dimethylcyclohexane PFDMC *, Perfluoro Decalin,  Perfluoro Nonane,  Perfluoro(methlydecalin),  Perfluoro-1,3,5 – Trimethylcyclohexane,   Perfumes *,  Petrosine,   PFD ?,  Phosphors,         Photochromic dyes, Phthalic anhydride, Pigment (Red, Blue, Magenta),   Polychlorinated biphenyls (PCB), Polyglycoldiamine H221, Polysulfone,  Potassium aluminum sulfate,   Potassium Chloride,  Potassium fluoride,   Potassium Fluoroborate,  Potassium Iodide,  Potassium Sulfate,  Prills,     PVC Resin,   PVME – Adhesive

    R

    181.   Red Dye,  Rutile

    S

    183.   Samarium Cobalt SMCO5,  Scent,  Scripset, Sludge, Sodium    Arsenate, Sodium borate,Sodium Chloride, Sodium Hydroxide (5% concentration), Sodium Hypochlorite, Sodium laurel sulfate, Sodium pentahydrate, Sodium Tetraborate *, Stearic acid, Stearyl methacrylate,  Stoddard  Solvent,  Styrene acrylic resin, Styrene maleic anhydride,         Sugar * (Sucrose),   Sulfuric Acid (2% concentration)

    T

    202.   Terrazole *,  Tetraethylene glycol dimethacrylate (TEGDA),         Tetraethylene pentamine (TEPA),Triethylene tetramine (TETA),          Triethylene tetramine LiCl(TETA LiCl), Tetrahydrafuran,         Thermachromic Wax, TMTD – Rubber catalyst,  Toluene *,        Toluenesulfonic acid, Triasulfuron (herbicide), 1,1,1 Trichloroethane,         Trichloroethylene *,  Trichlorotrifluoroethane,  Trimethylpropane trimethacrylate,  Tung oil, Turtle wax

    V

    219.    VM & P Naptha,  Vaccine (Dry) *,Vanilla Cream Flavor

    W

    222.   Water/Glycerin 50/50 *,   Wizard Fire Starter  Wormwood Oil

    X

    225.          Xylene

    Z

    226.   Zinc stearate,   ZnCap,   Zyglo ZL 30A & 37

     

    Plus

    Bayberry wax, Cineole, Disodium Salt,                            d-Limonenedimercaptan (dLDM), Ethylenediaminetetraacetic acid, Isooctane,           Lauric acid, Lupersol 331-80B, Magnesium Hydroxide, Spermaceti wax, Tartaric acid, Tetraethylenepentamine/LiCl, Triethylenetetramine/LiCl, Trigonox 29B-75, Urea, Varox DBPH, Zinc oxide


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